On this website, we especially discuss our research findings from more than 50 years of systems biology studies which revealed that thiol (-SH)/disulfide (-S-S-) interchange protein and peptide electrochemistry and biophysics provide the epigenetic code-based universal dynamic mechanism by which environmental (whether abiotic or biotic) messenger chemical groups and energy states (e. g., stresses) are transduced into bioinformation which regulates the response(s) of the involved organism. We have repeatedly conducted the acid test regarding whether such -SH/-S-S- interchange chemistry is really the involved unifying transduction mechanism, by utilizing classical reagents for thiols or disulfides to alter the control; whole-organism response(s).
Unifinium found that the epigenetic code based bioinformational process in all cases is readily characterized both qualitatively and quantitatively (e.g., in millivolts, mV). We found that the values (e.g., mVs) measured at multiple levels (i. e., locations) in the whole organism are so highly correlated, that measurement of the response at single organizational levels in the organism can accurately predict the response of the whole life form (e. g., live insect). We first theorized that -SH/-S-S- exchange was this unifying transduction mechanism in the nervous system in a paper published in Experientia in 1971.
Our long-term experimental focus on the epigenetic code has been in the chemical senses of insects (Nature, 1969; Science, 1970, etc.), but many pertinent studies have been conducted in both intact herbaceous and woody plants, fungi and bacteria; and more recently have been extended very successfully to viruses (please see pertinent references to our published papers in library).
